| Effect | positive |
|---|---|
| Mechanism | phosphorylation |
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:3725:out-urn:agi-llid:1432::positive |
| Nodes | JUN --+> MAPK14 |
| References | 5 |
| Connectivity | 2 |
| Journal | J. Immunol |
|---|---|
| Journal Reference | v165 i1 p419 (2000) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/165/1/419 |
| MedLine Reference | 10861080:1028 |
| Sentence | We show that GBS interaction with cord blood monocytes induces host cell signal transduction pathways that result in activation of the transcription factors NF- B and AP-1 through a pathway that involves phosphorylation of the p38 MAPK. |
| MedLine Reference | 9379049:6 |
|---|---|
| Sentence | These findings suggest that TNF-alpha transiently phosphorylates and activates the three members of the MAPK family, namely p42(mapk/erk2), p46 c-Jun amino-terminal kinase/stress-activated protein kinase (JNK/SAPK), and p38mapk following cross-linking of CD120a (p55), and that MKK3 and MKK4 are capable of phosphorylating p38mapk. |
| MedLine Reference | 15555594:4 |
|---|---|
| Sentence | Analysis of the inhibitory mechanisms of furosin revealed that it inhibited the receptor activator of nuclear factor-kappaB ligand (RANKL)-induced activation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK)/activating protein-1 (AP-1). |
| MedLine Reference | 15730644:6 |
|---|
| MedLine Reference | 15581403:3 |
|---|