| Nodes | JUN --+> TP53 |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | positive |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:3725:out-urn:agi-llid:7157::positive |
| Journal | Cell Phys |
|---|---|
| Journal Reference | v281 i3 pC751 (2001) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/281/3/C751 |
| MedLine Reference | 11502552:1249 |
| Sentence | Once these dimerize, AP-1 can bind and activate the p53 promoter ( 17 ). |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i6 p897 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/6/897 |
| Sentence | Although c-Jun is suggested to affect basal levels of p53 mRNA (Schreiber et al., 1999 ), normal accumulation of p53 protein in response to UV radiation or other genotoxic challenges was observed in all the cell lines used in this study. |
| MedLine Reference | 15648263:11 |
|---|---|
| Sentence | Evidence also supports a proapoptotic role of the JNKs signaling pathway in vivo and clearly indicates that JNKs are required for phosphorylation of c-Jun, activation of p53, and subsequent apoptosis induced by polycarpines. |