| URN | urn:agi-Expression:inout-urn:agi-llid:3725:out-urn:agi-llid:7157::negative |
|---|---|
| Nodes | JUN ---| TP53 |
| References | 6 |
| Connectivity | 2 |
| Effect | negative |
| MedLine Reference | 12145210:1017 |
|---|---|
| Sentence | AP-1 proteins are usually activated in response to stress signals, such as UV irradiation, but also by growth factor pathways, and promote mitogen-induced cell-cycle progression or regulate apoptosis by modulating cyclin D1 and p53 expression ( Schreiber et al ., 1999 ; Wisdom et al ., 1999 ). |
| MedLine Reference | 12654005:1204 |
|---|---|
| Sentence | The increased levels of c-Jun up-regulate cyclin D 1 expression and inhibit the transcription of p53 and p21 . |
| MedLine Reference | 10072388:1009 |
|---|
| MedLine Reference | 10747965:1284 |
|---|
| MedLine Reference | 12896981:1196 |
|---|
| MedLine Reference | 11739718:1230 |
|---|