| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-enz:3.4.22.17::positive |
| Nodes | TP53 --+> calpain |
| References | 1 |
| Connectivity | 2 |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v17 i5 p2806 (1997) |
| Journal Link | http://mcb.asm.org/cgi/content/full/17/5/2806 |
| Sentence | Briefiy, p53 wasproduced by translation in a rabbit reticulocyte lysate, which isdevoid of any detectable calpain activity, and then mixed withan S100 human Jurkat or Daudi cell cytoplasmic extract, whichcontains the calpain activity, and ffnally degradation reactionswere started by adding calcium for activating calpains. |