| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-go:0005125::unknown |
| Nodes | MAPK14 ---> cytokine activity |
| References | 34 |
| Connectivity | 2 |
| MedLine Reference | 11689443:1011 |
|---|---|
| Sentence | Two mammalian MAPKs, c-Jun N-terminal kinase (JNK) and p38 MAPK, are known to be activated by various environmental stresses and regulate diverse cellular functions including cytokine production, differentiation and apoptosis ( Nishida and Gotoh, 1993 ; Xia et al ., 1995 ; Kyriakis and Avruch, 1996 ; Ichijo, 1999 ; Widmann et al ., 1999 ; Davis, 2000 ; Ono and Han, 2000 ; Matsuzawa and Ichijo, 2001 ). |
| MedLine Reference | 11477091:1013 |
|---|---|
| Sentence | Involvement of phosphatidylinositol 3-kinase and p38 MAPK in the TLR-mediated induction of several cytokine and chemokine messages was demonstrated using specific inhibitors. |
| MedLine Reference | 11823457:1022 |
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| MedLine Reference | 12048217:1193 |
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| MedLine Reference | 10097111:1114 |
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