| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-go:0003930::unknown |
| Nodes | TP53 ---> RAS small monomeric GTPase |
| References | 16 |
| Connectivity | 2 |
| MedLine Reference | 11059788:1011 |
|---|---|
| Sentence | In similar experiments, cotransfection of wt p53 or 14/19 p53 resulted in significant inhibition of oncogenic transformation in rat embryo fibroblast mediated by an activated ras plus c- myc , adenovirus E1A , or human papillomavirus E7 oncogenes. |
| MedLine Reference | 12543805:1004 |
|---|---|
| Sentence | However, additional molecular aberrations including p53 inactivation, ras activation, and deregulation of protein phosphatase 2A activity are necessary for full transformation of immortalized epithelial cells. |
| MedLine Reference | 11408351:1022 |
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| MedLine Reference | 11574421:1128 |
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| MedLine Reference | 11568302:1058 |
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| MedLine Reference | 11296226:1019 |
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| MedLine Reference | 12411481:1032 |
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| MedLine Reference | 12628936:1025 |
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| MedLine Reference | 10950866:1172 |
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| MedLine Reference | 10978315:1018 |
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| MedLine Reference | 2426467:2 |
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| MedLine Reference | 8760300:5 |
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| MedLine Reference | 9366525:8 |
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| MedLine Reference | 10205143:2 |
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| MedLine Reference | 11940651:1042 |
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| MedLine Reference | 9294187:1041 |
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