| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:relaxation::positive |
| Nodes | MAPK14 --+> relaxation |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 15194473:6 |
|---|---|
| Sentence | Inhibition of p38 MAP kinase by treatment with the p38 MAP kinase inhibitor SB239063 (800 ppm in standard rat chow) reduced MAPKAPK-2 phosphorylation, preserved acetylcholine-induced relaxation (R(max): 80+/-4%, p<0.01), and reduced vascular superoxide formation. |
| MedLine Reference | 15199093:2 |
|---|---|
| Sentence | The relaxation was abolished by specific inhibitors of cyclooxygenase (COX)-1, COX-2, mitogen-activated protein kinase kinase (MEK), and p38 MAP kinase. |