| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:senescence::positive |
| Nodes | MAPK14 --+> senescence |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 11971971:3 |
|---|---|
| Sentence | Constitutive activation of p38 by active MKK3 or MKK6 induces senescence. |
| MedLine Reference | 12581156:3 |
|---|---|
| Sentence | We demonstrate that p38 mitogen-activated protein kinase (MAPK) plays important causative roles in senescent cells following telomere shortening, Ras-Raf activation, oxidative stress or inappropriate culture conditions. |