| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:dna%20fragmentation::positive |
| Nodes | MAPK14 --+> dna fragmentation |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 10837470:3 |
|---|---|
| Sentence | Preincubation of cells with SB203580, a specific inhibitor of p38, dose dependently inhibited DNA fragmentation induced by singlet oxygen but not by H(2)O(2). |
| MedLine Reference | 12805646:9 |
|---|---|
| Sentence | Inhibition of p38 MAP kinase by SB203580 blocked all downstream effects of Bax translocation, including cytochrome c release, caspase activation, and internucleosomal DNA fragmentation. |
| MedLine Reference | 11604490:1192 |
|---|