| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:G2phase::unknown |
| Nodes | MAPK14 ---> G2 phase |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 12937170:1205 |
|---|---|
| Sentence | To further determine whether increased p38 kinase activation in SHP-2Delta/Delta cells might be responsible for the decreased G2 arrest response in SHP-2 mutant cells, we treated the cells with cisplatin in combination with SB203580 , a selective inhibitor of p38 kinase. |
| MedLine Reference | 12496360:1291 |
|---|---|
| Sentence | Thus, our study showed that MnSOD effectively rescues cells from radiation-mediated cell death through the G2 checkpoint requiring p38MAPK activation and that p38MAPK is activated by increased H 2 O 2 generation in these cells. |
| MedLine Reference | 11756692:1016 |
|---|