| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:proteolysis::negative |
| Nodes | TP53 ---| proteolysis |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 12421820:1121 |
|---|---|
| Sentence | Thus, with several technical breakthroughs, we have demonstrated for the first time that acetylation of p53 directly inhibits ubiquitination-dependent proteolysis. |
| MedLine Reference | 11713288:1015 |
|---|---|
| Sentence | An important regulator of p53 protein level is MDM2, which possesses intrinsic E3 ligase activity and thus promotes p53 ubiquitination and subsequent degradation via proteasome-mediated proteolysis ( 2 ). |