Regulation :


Effect	unknown
URN	urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:inflammation::unknown
Nodes	TP53 ---> inflammation
References	3
Connectivity	2


MedLine Reference	11080152:1210
Sentence	Wild- type p53 is cytoplasmic in inflammatory breast carcinoma ( Moll et al ., 1992 ), undifferentiated neuroblastomas ( Moll et al ., 1995 ), colon adenocarcinomas ( Bosari et al ., 1995 ), differentiated rat oligodendrocytes, neurons and PC12 pheochromocytoma cells ( Eizenberg et al ., 1996 ), neuroblastoma cell lines ( Moll et al ., 1996 ), Balb/c 3T3 cells in certain stages of the cell cycle ( Shaulsky et al ., 1990 ) and normal mouse embryonic stem cells ( Aladjem et al ., 1998 ).

MedLine Reference

11080152:1210

Sentence

Wild- type p53 is cytoplasmic in inflammatory breast carcinoma ( Moll et al ., 1992 ), undifferentiated neuroblastomas ( Moll et al ., 1995 ), colon adenocarcinomas ( Bosari et al ., 1995 ), differentiated rat oligodendrocytes, neurons and PC12 pheochromocytoma cells ( Eizenberg et al ., 1996 ), neuroblastoma cell lines ( Moll et al ., 1996 ), Balb/c 3T3 cells in certain stages of the cell cycle ( Shaulsky et al ., 1990 ) and normal mouse embryonic stem cells ( Aladjem et al ., 1998 ).


MedLine Reference	11786406:5
Sentence	Therefore, p53 expression occurs during inflammation and acts to suppress local inflammatory responses.


MedLine Reference	15574763:6
Sentence	In environmental cigarette smoke-exposed mice, the p53 mutation resulted in a lack of induction of proapoptotic genes and in overexpression of genes involved in cell proliferation, signal transduction, angiogenesis, inflammation, and immune response.