| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-cellproc:synthesis::negative |
| Nodes | TP53 ---| synthesis |
| References | 10 |
| Connectivity | 2 |
| MedLine Reference | 11756229:1022 |
|---|---|
| Sentence | Additionally, p53 is also rapidly induced following UV irradiation, and the increased p53 is part of a protective response which blocks cell cycle progression to allow time for repair of DNA damage before further synthesis and mitosis ( 7 ). |
| MedLine Reference | 11517158:1029 |
|---|---|
| Sentence | These factors, as well as p53, have been reported to increase the synthesis and secretion of IGFBP-3 ( 17 , 19 , 20 , 21 , 23 ). |
| MedLine Reference | 1295451:4 |
|---|
| MedLine Reference | 9771485:2 |
|---|
| MedLine Reference | 10913176:1044 |
|---|
| MedLine Reference | 11884608:1026 |
|---|
| MedLine Reference | 9891091:1037 |
|---|
| MedLine Reference | 9843965:1177 |
|---|
| MedLine Reference | 15331412:0 |
|---|---|
| Sentence | Inhibition of p53-induced epidermal apoptosis, generation of p53 mutations, and suppressor T cells are the critical events responsible for the induction and development of UV-induced skin cancers. |
| MedLine Reference | 15345715:7 |
|---|