| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:transformation::positive |
| Nodes | MAPK14 --+> transformation |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 12499274:1278 |
|---|---|
| Sentence | Indeed, a recent report clearly demonstrates that p38 MAPK is a critical tumor suppressor protecting against E1A and H-Ras-induced transformation of mouse embryonic fibroblasts (75) . |
| MedLine Reference | 12748197:1006 |
|---|---|
| Sentence | Our data show that a dominant negative mutant of p38 MAP (DN-p38) kinase inhibits EGF-promoted JB6 Cl41 cell transformation and that SB202190 , an inhibitor of p38 MAP kinase, also inhibits JB6 Cl41 cell transformation in a dose-dependent manner. |