Regulation :

Effect unknown
URN urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:regulation%20of%20signal%20transduction::unknown
Nodes MAPK14 ---> regulation of signal transduction
References 24
Connectivity 2

Journal JPET
Journal Reference v301 i1 p15 (2002)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/301/1/15
MedLine Reference 11907152:1202
Sentence Activation of p38 MAPK (phosphorylation), mediated by "upstream" signaling kinases MKK6 or 3, participates in signal transduction initiated by a variety of cytokines, growth factors, and G-protein-coupled receptors, as well as chemical and mechanical cellular stress (Widmann et al., 1999 ).

MedLine Reference 12082020:1309
Sentence In particular, the p38 kinase is known to play a key role in the LPS-induced signal transduction pathway ( 32, 60 ).

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Sentence Therefore, p38 MAP kinase is necessary for the downstream signal transduction of ASK1-induced differentiation.

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