| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:1432:out-urn:agi-cellproc:g2-m%20transition::unknown |
| Nodes | MAPK14 ---> g2-m transition |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 12499274:1196 |
|---|---|
| Sentence | Recent studies demonstrated that JNK and p38 MAPK are not only involved in p53 phosphorylation and activation (18 , 19) , but that p38 MAPK also mediates activation of a G2/M checkpoint by phosphorylating Cdc25B (25) . |
| MedLine Reference | 12726921:7 |
|---|---|
| Sentence | ROS activate ERK and p38, which in turn upregulate p21 and cdc2 and cause degradation of cdc25C, leading to cell growth arrest at the G(2)/M phase. |