| Connectivity | 970 |
|---|---|
| Notes | EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. |
| Hugo ID | 3373 |
| Name | EP300 |
| Description | E1A binding protein p300 |
| URN | urn:agi-llid:2033 |
| GO Cellular Component | histone acetyltransferase complex |
|---|---|
| nucleus | |
| transcription factor complex |
| Cell Localization | Nucleus |
|---|
| GO Biological Process | heart development |
|---|---|
| lung development | |
| myogenesis | |
| organogenesis | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| apoptosis | |
| cell cycle | |
| neurogenesis | |
| signal transduction | |
| transcription from Pol II promoter |
| MGI ID | 1276116 |
|---|
| Swiss-Prot Accession | Q09472 |
|---|
| OMIM ID | OMIM:602700 |
|---|---|
| OMIM:114500 |
| Alias | Ep300 |
|---|---|
| E1A binding protein p300 | |
| p300 | |
| A430090G16 | |
| A730011L11 | |
| E1A-binding protein, 300kD | |
| P300_HUMAN | |
| transcription adaptor protein p300 | |
| 300 kDa E1A-binding protein | |
| 4930432K09Rik | |
| CBP/p300 | |
| E1A-associated protein p300 | |
| hypothetical protein A430090G16 | |
| hypothetical protein A730011L11 | |
| p300/CBP | |
| RIKEN cDNA 4930432K09 gene | |
| transcription adaptor p300 |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 170915 |
|---|---|
| 13816 | |
| 214392 | |
| 328572 | |
| 2033 |
| RGD ID | 620036 |
|---|
| Pathway | TGF-beta signaling |
|---|---|
| Control of skeletal myogenesis | |
| moduleb_proteins | |
| moduled_proteins | |
| modulee_proteins | |
| moduleg_direct | |
| moduleg_shortest | |
| modulef_direct |
| Unigene ID | Rn.48331 |
|---|---|
| Mm.258397 | |
| Hs.271730 |
| Group | Transcription factors |
|---|---|
| protein binding | |
| metal ion binding |