| Connectivity | 777 |
|---|---|
| Notes | Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM] |
| Hugo ID | 4617 |
| Name | GSK3B |
| Description | glycogen synthase kinase 3 beta |
| URN | urn:agi-llid:2932 |
| GO Cellular Component | cytosol |
|---|---|
| nucleus |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO Biological Process | establishment and/or maintenance of cell polarity |
|---|---|
| establishment of cell polarity | |
| induction of apoptosis | |
| negative regulation of transcription, DNA-dependent | |
| protein amino acid phosphorylation | |
| Wnt receptor signaling pathway | |
| adipocyte differentiation | |
| anti-apoptosis | |
| cell proliferation | |
| organogenesis | |
| protein-nucleus export | |
| re-entry into mitotic cell cycle | |
| response to stress | |
| glycogen metabolism |
| EC Number | 2.7.1.37 |
|---|
| MGI ID | 1861437 |
|---|
| Swiss-Prot Accession | P49841 |
|---|
| OMIM ID | OMIM:605004 |
|---|
| Alias | Gsk3b |
|---|---|
| glycogen synthase kinase 3 beta | |
| GSK3 | |
| GSK-3 | |
| GSK3-beta | |
| GSK-3beta | |
| 7330414F15Rik | |
| 8430431H08Rik | |
| KG3B | |
| KG3B_HUMAN | |
| protein kinase | |
| GSK3beta | |
| C86142 | |
| expressed sequence C86142 | |
| Glycogen synthase kinase-3 beta | |
| GSK III | |
| GSK-3 beta | |
| RIKEN cDNA 7330414F15 gene | |
| RIKEN cDNA 8430431H08 gene |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 84027 |
|---|---|
| 56493 | |
| 56637 | |
| 66806 | |
| 78144 | |
| 98033 | |
| 2932 |
| RGD ID | 70982 |
|---|
| Pathway | Wnt signaling |
|---|---|
| moduleb_proteins | |
| moduled_proteins | |
| modulee_proteins | |
| moduleg_direct | |
| moduleg_shortest | |
| modulef_direct |
| Unigene ID | Rn.10426 |
|---|---|
| Mm.200770 | |
| Hs.282359 |
| Group | Kinases |
|---|---|
| nucleotide binding |