Protein : TP53


Connectivity	3171
Notes	Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Hugo ID	11998
Name	TP53
Description	transformation related protein 53
URN	urn:agi-llid:7157


Cell Localization	Nucleus


GO Biological Process	DNA damage response, signal transduction by p53 class mediator
	apoptosis
	negative regulation of cell cycle
	negative regulation of cell growth
	protein-nucleus import, translocation
	regulation of transcription from Pol II promoter
	regulation of transcription, DNA-dependent
	transcription
	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
	cell cycle
	negative regulation of DNA replication
	negative regulation of apoptosis
	negative regulation of fibroblast proliferation
	regulation of cell proliferation
	response to DNA damage stimulus
	response to UV
	response to X-ray
	caspase activation via cytochrome c
	cell aging
	cell cycle arrest
	cell cycle checkpoint
	cell differentiation
	cell proliferation
	induction of apoptosis by hormones
	negative regulation of helicase activity
	nucleotide-excision repair
	regulation of mitochondrial membrane permeability


MGI ID	98834


Swiss-Prot Accession	P04637


Alias	Tp53
	p53
	Trp53
	tumor protein p53 (Li-Fraumeni syndrome)
	transformation related protein 53
	P53_HUMAN
	cellular tumor antigen p53
	Phosphoprotein p53
	similar to p53 alternative splice isoform p35/HAS
	similar to transformation related protein 53
	tumor protein p53
	Tumor suppressor p53
	P-53


RGD ID	3889


Pathway	RB Tumor Suppressor
	SAPK-JNK Signaling
	Mitochondrial control of Apoptosis
	p53 Signaling
	ATM signaling
	Apoptosis
	moduleb_direct interactions
	moduleb_shortest paths
	moduleb_commontarget-complex
	moduleb_commontargets-functionalclass
	moduleb_commontarget_cell processes
	moduleb_proteins
	moduled_direct interactions
	moduled_shortest paths
	moduled_proteins
	moduled_complex
	moduled_functional class
	moduled_cell process
	modulee_direct
	modulee_shortest
	modulee_proteins
	modulee_complex
	modulee_functionalclass
	modulee_cellprocesses
	Copy of 'New Pathway'
	moduleg_direct
	moduleg_shortest
	moduleg_complex
	moduleg_protein
	moduleg_functionalclass
	moduleg_cellprocesses
	modulef_direct