| Connectivity | 52 |
|---|---|
| Notes | The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2 |
| Hugo ID | 6974 |
| Name | MDM4 |
| Description | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) |
| URN | urn:agi-llid:4194 |
| GO Cellular Component | nucleus |
|---|---|
| ubiquitin ligase complex |
| Cell Localization | Nucleus |
|---|
| GO Biological Process | protein ubiquitination |
|---|---|
| G0 to G1 transition | |
| apoptosis | |
| cell proliferation | |
| negative regulation of cell proliferation | |
| negative regulation of protein catabolism | |
| negative regulation of transcription from Pol II promoter | |
| protein complex assembly | |
| protein stabilization |
| MGI ID | 107934 |
|---|
| Swiss-Prot Accession | O15151 |
|---|
| OMIM ID | OMIM:602704 |
|---|
| Alias | Mdm4 |
|---|---|
| Mdmx | |
| transformed mouse 3T3 cell double minute 4 | |
| MDM4_MOUSE | |
| MDM2-like p53-binding protein MDMX | |
| Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | |
| p53-binding protein | |
| mouse double minute 4, human homolog of; p53-binding protein | |
| mouse double minute 4 homolog | |
| MDM4_HUMAN | |
| Mdm4 protein | |
| C85810 | |
| double minute 4 homolog | |
| Double minute 4 protein | |
| Mdm2-like p53-binding protein | |
| Mdmx protein | |
| P53-binding protein Mdm4 | |
| transformed mouse 3T3 cell double minute IV | |
| expressed sequence C85810 |
| Organism | Mus musculus |
|---|---|
| Human |
| LocusLink ID | 17248 |
|---|---|
| 96920 | |
| 98200 | |
| 98493 | |
| 98530 | |
| 98570 | |
| 263724 | |
| 269117 | |
| 4194 |
| Pathway | moduled_proteins |
|---|---|
| moduleg_direct | |
| moduleg_shortest | |
| modulef_direct |
| Unigene ID | Mm.326936 |
|---|---|
| Hs.432374 |
| Group | protein binding |
|---|---|
| metal ion binding |