| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::positive |
| Nodes | MDM2 --+> TP53 |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 15257544:2 |
|---|---|
| Sentence | P14(ARF) blocks MDM2-induced p53 degradation and transactivational silencing. |
| MedLine Reference | 15314174:5 |
|---|---|
| Sentence | We show that, when overexpressed, L23 inhibits HDM2-induced p53 polyubiquitination and degradation and causes a p53-dependent cell cycle arrest. |