| URN | urn:agi-ProtModification:inout-urn:agi-llid:7157: |
|---|---|
| Nodes | TP53; GSK3B; HDAC5; PTCH; MAPK14; MMS; YY1; PPP1R15A; CHEK2; cadmium; cisplatin; EP300; MDM2; MDM4; histone deacetylase; ATM |
| Modification Type | phosphorylation |
| References | 13 |
| Connectivity | 16 |
| MedLine Reference | 15107622:4 |
|---|---|
| Sentence | This process requires the phosphorylation of p53 at serine 315 and serine 376, which is mediated by the activation of glycogen synthase kinase-3beta (GSK-3beta). |
| MedLine Reference | 12019172:4 |
|---|---|
| Sentence | Furthermore, HDAC5 does not bind to p53 nor reduces etoposide-induced p53 acetylation. |
| MedLine Reference | 15142440:9 |
|---|---|
| Sentence | PTC1 may remain ATM kinase in cytoplasm and inhibit the phosphorylation of p53 by ATM. |
| MedLine Reference | 11245472:4 |
|---|
| MedLine Reference | 11494044:9 |
|---|
| MedLine Reference | 15295102:3 |
|---|
| MedLine Reference | 14635196:6 |
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| MedLine Reference | 15269203:9 |
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| MedLine Reference | 11302731:6 |
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| MedLine Reference | 11326311:1 |
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| MedLine Reference | 12162806:0 |
|---|
| MedLine Reference | 15361854:4 |
|---|
| MedLine Reference | 15177039:2 |
|---|