| Effect | unknown |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:7157:out-urn:agi-llid:4193::unknown |
| Nodes | TP53 ---> MDM2 |
| Modification Type | phosphorylation |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 12668979:1 |
|---|---|
| Sentence | Recent data show that cyclin G1 can regulate the levels of p53 by a mechanism that involves dephosphorylation of Mdm2 by protein phosphatase 2A. |
| MedLine Reference | 12954980:1215 |
|---|---|
| Sentence | One mechanism for this action could involve an Akt-mediated phosphorylation of Mdm2, facilitating nuclear localization of Mdm2 and degradation of p53 ( 38 , 48 ). |