| URN | urn:agi-MolSynthesis:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::negative |
|---|---|
| Nodes | MDM2 ---| TP53 |
| References | 3 |
| Connectivity | 2 |
| Effect | negative |
| MedLine Reference | 10074902:1112 |
|---|---|
| Sentence | The stabilization of endogenous p53 by these Mdm2 mutants strongly supports previous studies showing that Mdm2 is responsible for the turnover of p53 in undamaged cells (6) . |
| MedLine Reference | 9649502:1076 |
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| Sentence | Furthermore, Mdm2 induced by the Ras/Raf/MEK/MAP kinase pathway is functionally active and leads to degradation of p53. |
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