| URN | urn:agi-Expression:inout-urn:agi-llid:7157:out-urn:agi-llid:4193::positive |
|---|---|
| Nodes | TP53 --+> MDM2 |
| References | 16 |
| Connectivity | 2 |
| Effect | positive |
| Journal | AJRCMB |
|---|---|
| Journal Reference | v22 i6 p747 (2000) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/22/6/747 |
| MedLine Reference | 10837373:1238 |
| Journal | Cell |
|---|---|
| Journal Reference | v91 i3 p325 (1997) |
| Journal Link | http://www.cell.com/cgi/content/full/91/3/325 |
| Journal | EMBO |
|---|---|
| Journal Reference | v19 i18 p4967 (2000) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/19/18/4967 |
| MedLine Reference | 10990460:1071 |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v19 i4 p2475 (1999) |
| Journal Link | http://mcb.asm.org/cgi/content/full/19/4/2475 |
| MedLine Reference | 10082513:1041 |
| MedLine Reference | 10626796:1157 |
|---|---|
| Sentence | The activity of p53 is regulated by the Mdm2 protein, which can bind to p53 and inhibits p53-mediated transcriptional activation of several genes including MDM2 itself (for review, see Ref. 24 ). |
| MedLine Reference | 10749144:1232 |
|---|---|
| Sentence | The mdm2 P2 promoter is constitutively sensitive to DNase I, but when p53 activates mdm2 transcription, no increase in this sensitivity occurs (17) . |
| MedLine Reference | 10766163:1149 |
|---|
| MedLine Reference | 11059788:1113 |
|---|
| MedLine Reference | 11245471:1047 |
|---|
| MedLine Reference | 11888896:1138 |
|---|
| MedLine Reference | 12750288:1411 |
|---|
| MedLine Reference | 12839945:1114 |
|---|
| MedLine Reference | 11323395:1018 |
|---|
| MedLine Reference | 10593650:1160 |
|---|
| MedLine Reference | 10562557:1024 |
|---|
| MedLine Reference | 15279792:1 |
|---|---|
| Sentence | Expression of the mdm2 gene is stimulated by p53 and this reciprocal relationship forms the basis of a negative feedback loop. |