| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-llid:7157::negative:acetylation |
| Mechanism | acetylation |
| Nodes | MDM2 ---| TP53 |
| References | 56 |
| Connectivity | 2 |
| MedLine Reference | 11159535:1080 |
|---|---|
| Sentence | These results indicate that mdm2 AS induces apoptosis of the cells that contain MDM2 protein (whether this protein is overexpressed or not) and wild-type p53 (whether this protein accumulates after AS treatment or not) but have no effects on the viability of the cells that contain MDM2 and mutated p53 or MDM2 and no p53. |
| MedLine Reference | 10344759:1123 |
|---|---|
| Sentence | Mdm2 , in turn, is a p53-responsive gene whose product acts through negative feedback to inhibit p53 transactivation (51 , 52) and to accelerate p53 turnover (53 , 54 , 55 , 56) . |
| MedLine Reference | 10446990:1021 |
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