| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:transformation::unknown |
| Nodes | MDM2 ---> transformation |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 8529093:7 |
|---|---|
| Sentence | When mdm-2 is overproduced, resulting in a tumor or transformation of a cell, all of the p53 activities are inactivated. |
| MedLine Reference | 14587869:1 |
|---|---|
| Sentence | The Mdm2 protein is a key regulator of cell growth and death and plays a pivotal role in the transformation of normal cells into tumor cells, the hallmark of an oncogene. |