| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:maturation::unknown |
| Nodes | MDM2 ---> maturation |
| References | 4 |
| Connectivity | 2 |
| MedLine Reference | 12477391:0 |
|---|---|
| Sentence | p53 and its main negative regulator, Mdm2, are key players in mammalian cancer development. |
| MedLine Reference | 9087426:3 |
|---|---|
| Sentence | In six different transgenic mouse lines, deregulated expression of MDM2 inhibited normal development and morphogenesis of the mammary gland, and caused cellular hypertrophy and nuclear abnormalities. |
| MedLine Reference | 10389975:1 |
|---|
| MedLine Reference | 15720187:1 |
|---|---|
| Sentence | Because of its prevalent expression and its interactions with p53 and other signaling molecules, MDM2 plays a central role in cancer development and progression. |