| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-cellproc:senescence::unknown |
| Nodes | MDM2 ---> senescence |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 11781307:1291 |
|---|---|
| Sentence | ERalpha-induced MDM2 may block the p53 function that induces growth arrest and senescence of cancer cells, allowing progression of cancer cells with wt p53 to those with more invasive characters. |
| MedLine Reference | 11739733:1276 |
|---|---|
| Sentence | However, earlier work showed that endogenous Mdm2 accumulated in nucleoli with ARF in MEFs overexpressing Myc or undergoing cellular senescence ( 62 ). |