| Connectivity | 612 |
|---|---|
| Notes | Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM] |
| Hugo ID | 2514 |
| Name | CTNNB1 |
| Description | catenin beta |
| URN | urn:agi-llid:1499 |
| GO Cellular Component | cytoplasm |
|---|---|
| cytoskeleton | |
| adherens junction | |
| apical part of cell | |
| basolateral plasma membrane | |
| intercellular junction | |
| membrane | |
| membrane fraction | |
| nucleus | |
| transcription factor complex | |
| plasma membrane |
| Cell Localization | Nucleus |
|---|
| GO Biological Process | Wnt receptor signaling pathway |
|---|---|
| cell adhesion | |
| cell growth and/or maintenance | |
| ectoderm development | |
| gastrulation (sensu Mammalia) | |
| heart development | |
| hemopoiesis | |
| lung development | |
| patterning of blood vessels | |
| proximal/distal pattern formation | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| synapse organization and biogenesis | |
| synaptic transmission | |
| synaptic vesicle transport | |
| transcription |
| MGI ID | 88276 |
|---|
| Swiss-Prot Accession | P35222 |
|---|
| OMIM ID | OMIM:116806 |
|---|---|
| OMIM:114550 | |
| OMIM:132600 |
| Alias | Catnb |
|---|---|
| Ctnnb1 | |
| beta-catenin | |
| catenin beta | |
| catenin (cadherin-associated protein), beta 1 (88kD) | |
| cadherin associated protein | |
| A730098P15 | |
| hypothetical protein A730098P15 | |
| CTNNB | |
| CTNB | |
| catenin (cadherin-associated protein), beta 1, 88kDa | |
| catenin (cadherin-associated protein), beta 1 (88kDa | |
| CTNB_HUMAN | |
| beta 1 catenin | |
| Beta-cat | |
| catenin beta 1 | |
| catenin beta I | |
| Ctnnb I | |
| LOC316084 | |
| 88 kDa catenin (cadherin-associated protein), beta 1 |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 84353 |
|---|---|
| 252926 | |
| 12387 | |
| 209012 | |
| 1499 |
| RGD ID | 70487 |
|---|---|
| 620703 |
| Pathway | Wnt signaling |
|---|---|
| moduleb_proteins | |
| modulee_direct | |
| modulee_shortest |
| Unigene ID | Rn.112601 |
|---|---|
| Mm.291928 | |
| Mm.335539 | |
| Hs.410086 |
| Group | Transcription factors |
|---|---|
| protein binding | |
| modulee |