| URN | urn:agi-Expression:inout-urn:agi-llid:1499:out-urn:agi-llid:4609::positive |
|---|---|
| Nodes | CTNNB1 --+> MYC |
| References | 6 |
| Connectivity | 2 |
| Effect | positive |
| MedLine Reference | 11956582:1 |
|---|---|
| Sentence | Uncomplexed beta-catenin binds to TCF/LEF transcription factors and activates the expression of growth regulatory target genes such as c-myc or cyclin D1. |
| MedLine Reference | 12209953:11 |
|---|---|
| Sentence | While dysregulated beta-catenin may cause a transcriptional upregulation of the c-myc gene, the c-Myc protein expression appears to be further regulated by a posttranscriptional mechanism(s) during the process of neoplastic progression. |
| MedLine Reference | 12460931:7 |
|---|
| MedLine Reference | 12557145:6 |
|---|
| MedLine Reference | 9727977:3 |
|---|
| MedLine Reference | 15270885:4 |
|---|