| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-enz:3.4.22.-::positive |
| Nodes | TP53 --+> 3.4.22.- |
| References | 1 |
| Connectivity | 2 |
| Journal | PNAS |
|---|---|
| Journal Reference | v96 i5 p2147 (1999) |
| Journal Link | http://www.pnas.org/cgi/content/full/96/5/2147 |
| MedLine Reference | 10051609:1025 |
| Sentence | First, p53 induces apoptosis, a tightly regulated pathway of programmed cell death involving changes in mitochondrial physiology, cysteine protease activation, and DNA degradation ( 9-11 ). |