| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-smol:pip3:out-urn:agi-go:0008268::positive |
| Nodes | PIP3 --+> receptor tyrosine kinase |
| References | 2 |
| Connectivity | 2 |
| Journal | Cell |
|---|---|
| Journal Reference | v100 i6 p603.1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/100/6/603.1 |
| Sentence | PIP3 and PtdIns(3,4)P2 activate protein kinase B/Akt, which negatively regulates at least one receptor tyrosine kinase substrate that in turn desensitizes PI3K (Li et al., 1999 ). |
| Journal | Cell |
|---|---|
| Journal Reference | v100 i6 p603 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/100/6/603 |
| Sentence | PIP3 and PtdIns(3,4)P2 activate protein kinase B/Akt, which negatively regulates at least one receptor tyrosine kinase substrate that in turn desensitizes PI3K (Li et al., 1999 ). |