| Effect | unknown |
|---|---|
| URN | urn:agi-ProtModification:in-urn:agi-llid:207:inout-urn:agi-go:0004711::unknown |
| Nodes | AKT1 ---> RPS6K |
| Modification Type | phosphorylation |
| References | 17 |
| Connectivity | 2 |
| MedLine Reference | 11443130:1033 |
|---|---|
| Sentence | Akt inhibits many proapoptotic targets by phosphorylating caspase-9, glycogen synthase kinase, BCL-2-associated death promoter, and members of the forkhead family ( 6-12 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i35 p32814 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/35/32814 |
| MedLine Reference | 10559381:1229 |
|---|---|
| Sentence | LY 294002 inhibited Ras-induced phosphorylation of Akt, with no effect on the phosphorylation of MAPK, whereas PD 98059 inhibited Ras-induced phosphorylation of MAPK, with no effect on Akt (Fig. 6 A ). |
| Journal | J. Neurosci |
| Journal Reference | v19 i22 p9716 (1999) |
| Journal Link | http://www.jneurosci.org/cgi/content/full/19/22/9716 |
| MedLine Reference | 11520785:1075 |
|---|---|
| Sentence | Figure 2 B shows that LY294002 blocked Akt phosphorylation without altering MAP kinase phosphorylation and similarly U0126 blocked MAP kinase phosphorylation without altering Akt phosphorylation. |
| Journal | Blood |
| Journal Reference | v98 i5 p1374 (2001) |
| Journal Link | http://www.bloodjournal.org/cgi/content/full/98/5/1374 |
| MedLine Reference | 10383138:1130 |
|---|---|
| Journal | Cancer Res |
| Journal Reference | v59 i12 p2815 (1999) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/59/12/2815 |
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|---|---|
| Journal | Cell Growth and Diff |
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| Journal Link | http://cgd.aacrjournals.org/cgi/content/full/11/6/279.h |
| MedLine Reference | 12225966:1279 |
|---|---|
| Journal | Cell Phys |
| Journal Reference | v283 i4 pC1025 (2002) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/283/4/C1025 |
| MedLine Reference | 10748004:1266 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i20 p15458 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/20/15458 |
| MedLine Reference | 11134009:1294 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i12 p8856 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/12/8856 |
| MedLine Reference | 11934884:1040 |
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| Journal | J. Biol. Chem |
| Journal Reference | v277 i23 p20618 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/23/20618 |
| MedLine Reference | 12351629:1284 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i48 p46720 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/48/46720 |
| MedLine Reference | 12468535:1050 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i7 p4416 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/7/4416 |
| MedLine Reference | 12882977:1213 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i41 p39830 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/41/39830 |
| MedLine Reference | 9668041:1146 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v273 i30 p18705 (1998) |
| Journal Link | http://www.jbc.org/cgi/content/full/273/30/18705 |
| MedLine Reference | 11157988:1209 |
|---|---|
| Journal | J. Cell Biol |
| Journal Reference | v152 i3 p633 (2001) |
| Journal Link | http://www.jcb.org/cgi/content/full/152/3/633 |
| MedLine Reference | 9880587:1250 |
|---|---|
| Journal | J. Neurosci |
| Journal Reference | v19 i2 p664 (1999) |
| Journal Link | http://www.jneurosci.org/cgi/content/full/19/2/664 |
| MedLine Reference | 10727509:1082 |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v57 i4 p652 (2000) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/57/4/652 |
| MedLine Reference | 14612918:5 |
|---|