| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-go:0004711::positive |
| Nodes | TP53; RPS6K; cytokine activity |
| References | 15 |
| Connectivity | 3 |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.1 |
| Sentence | Thus, in normal cells, levels of p53 are determined by a balance between opposing effects of the Ras/Raf/MEK/MAP kinase pathway. |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321.2 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321.2 |
| Sentence | Thus, in normal cells, levels of p53 are determined by a balance between opposing effects of the Ras/Raf/MEK/MAP kinase pathway. |
| Journal | Cell |
|---|---|
| Journal Reference | v103 i2 p321 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/2/321 |
| Journal | EMBO |
|---|---|
| Journal Reference | v20 i8 p1931 (2001) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/20/8/1931 |
| MedLine Reference | 11296226:1009 |
| Journal | EMBO |
|---|---|
| Journal Reference | v21 i21 p5635 (2002) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/21/21/5635 |
| MedLine Reference | 12411481:1094 |
| Journal | EMBO |
|---|---|
| Journal Reference | v22 i6 p1289 (2003) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/22/6/1289 |
| MedLine Reference | 12628922:1024 |
| Journal | EMBO |
|---|---|
| Journal Reference | v22 i7 p1567 (2003) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/22/7/1567 |
| MedLine Reference | 12660163:1042 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i48 p37829 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/48/37829 |
| MedLine Reference | 10978315:1023 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i42 p41059 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/42/41059 |
| MedLine Reference | 12890671:1025 |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i16 p9354 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/16/9354 |
| MedLine Reference | 12878730:1114 |
| Journal | PNAS |
|---|---|
| Journal Reference | v94 i15 p7868 (1997) |
| Journal Link | http://www.pnas.org/cgi/content/full/94/15/7868 |
| MedLine Reference | 9223279:1023 |
| MedLine Reference | 10050883:7 |
|---|---|
| Sentence | Cytokine-induced activation of the MAPK pathway and the subsequent functional neutralization of p53, may be an event by which apoptosis is commonly suppressed in hematopoiesis. |
| MedLine Reference | 8972231:5 |
|---|
| MedLine Reference | 10890907:3 |
|---|
| MedLine Reference | 12673251:5 |
|---|