| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-go:0004693::positive |
| Nodes | AKT1 --+> cyclin-dependent protein kinase |
| References | 1 |
| Connectivity | 2 |
| MedLine Reference | 12146978:1 |
|---|---|
| Sentence | ACTH receptors activate the Galphas/adenylate cyclase cAMP/PKA pathway to promote dephosphorylation of Akt/PKB enzymes, leading to induction of the cyclin-dependent kinases' (CDKs) inhibitor p27(Kip1). |