| Effect | unknown |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-enz:1.6.99.6::unknown |
| Nodes | AKT1 ---> nadph oxidase |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 11211919:6 |
|---|---|
| Sentence | Furthermore, wortmannin but not BAPTA-AM and GF 109203X inhibited the fMLP-induced activation of Akt, which is known to regulate NADPH oxidase. |
| MedLine Reference | 15308572:4 |
|---|---|
| Sentence | Activation of phosphoinositol-3 kinase and Akt appears to mediate this NADPH oxidase activation through p47phox phosphorylation and Rac-1 activation. |