| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-protfc:tumor%20necrosis%20factor::positive |
| Nodes | AKT1 --+> tumor necrosis factor |
| References | 4 |
| Connectivity | 2 |
| MedLine Reference | 11779863:1276 |
|---|---|
| Sentence | The PI3K/Akt/mTOR pathway was shown to mediate TNF inhibition of insulin signaling through phosphorylation of serines 636 and 639 of IRS-1 ( 26 ). |
| MedLine Reference | 11799112:1269 |
|---|---|
| Sentence | Moreover, PTEN expression was unable to block the synergistic activation induced by M-Akt following TNF stimulation (Fig. 4 B ). |
| MedLine Reference | 10974038:1240 |
|---|
| MedLine Reference | 11287630:5 |
|---|