| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-go:0004842::positive |
| Nodes | AKT1 --+> E3 |
| References | 1 |
| Connectivity | 2 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v278 i14 p12361 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/14/12361 |
| MedLine Reference | 12517744:1210 |
| Sentence | Akt has been shown to activate the ubiquitin ligase activity of murine double minute-2, and murine double minute-2 activity has been implicated in Akt-stimulated increases in androgen receptor and p53 degradation ( 30 , 31 , 33 ). |