| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-go:0003720::negative |
| Nodes | TP53 ---| telomerase |
| References | 6 |
| Connectivity | 2 |
| Journal | AJRCMB |
|---|---|
| Journal Reference | v26 i5 p521 (2002) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/26/5/521 |
| MedLine Reference | 11970902:1071 |
| Sentence | Co-immunoprecipitation studies have shown that the tumor suppressor, p53, can associate with hTEP1 and telomerase and inhibit in vitro telomerase activity ( 49 ). |
| MedLine Reference | 11335714:1037 |
|---|---|
| Sentence | Several proteins such as p53, retinoblastoma (Rb ), 1 c-Myc, Bcl-2, protein kinase C, and protein phosphatase 2A have been shown to potentially regulate telomerase activity with transcriptional and posttranscriptional mechanisms ( 23 ). |
| MedLine Reference | 11441001:1235 |
|---|---|
| Sentence | In addition, recombinant p53 tumor suppressor protein has been shown to interact with TEP1 and inhibit telomerase activity in vitro , suggesting that telomerase might be a downstream target of p53 ( 64 ). |
| MedLine Reference | 10597287:3 |
|---|
| MedLine Reference | 11050287:6 |
|---|
| MedLine Reference | 15067344:2 |
|---|