| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-protfc:14-3-3::positive |
| Nodes | AKT1 --+> 14-3-3 |
| References | 4 |
| Connectivity | 2 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i32 p28706 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/32/28706 |
| MedLine Reference | 12042314:1050 |
| Sentence | Because Thr 198 -phosphorylated p27 Kip1 was localized only in the cytoplasm, Akt might promote 14-3-3 binding to p27 Kip1 by phosphorylation at Thr 198 , allowing its cytoplasmic localization and degradation. |
| MedLine Reference | 11438550:1009 |
|---|---|
| Sentence | We found that Akt inhibited the DNA binding activity of Nur77 and stimulated its association with 14-3-3 in a phosphorylation site-dependent manner. |
| MedLine Reference | 11864996:1227 |
|---|---|
| Sentence | We have shown that AKT-mediated phosphorylation of FKHRL1 at the 14-3-3 binding site within the nucleus results in accelerated nuclear export of FKHRL1. |
| MedLine Reference | 12757707:4 |
|---|