| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-go:0004674::negative |
| Nodes | MDM2 ---| protein serine/threonine kinase |
| References | 1 |
| Connectivity | 2 |
| MedLine Reference | 11729185:1092 |
|---|---|
| Sentence | Furthermore, Mdm2 levels decreased in proliferating MDA 468, T47D, and 293 cells treated with LY294002, which abrogated PI3K activity and therefore activation of its downstream target, the Akt serine-threonine kinase (Fig. 2 c ). |