| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:4193:out-urn:agi-go:0003930::positive |
| Nodes | MDM2 --+> RAS small monomeric GTPase |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 11507088:1258 |
|---|---|
| Sentence | MDM2 expression can be induced by p53-independent mechanisms such as p53 homologs p63 and p73, activated ras , and growth factors ( 39-41 ). |
| MedLine Reference | 11309506:1141 |
|---|---|
| Sentence | Although Mdm2 also accumulated in keratinocytes expressing oncogenic ras , it did not localize to the nucleolus (Fig. 4 C ). |