| URN | urn:agi-Expression:inout-urn:agi-llid:207:out-urn:agi-go:0003750::negative |
|---|---|
| Nodes | AKT1 ---| cell cycle regulator |
| References | 1 |
| Connectivity | 2 |
| Effect | negative |
| MedLine Reference | 10827191:1038 |
|---|---|
| Sentence | AKT can also phosphorylate and inactivate the AFX/Forkhead ( AFX/ FKHR ) family of transcription factors ( 19-22 ) which in turn suppresses AFX- mediated transcription of target genes such as the p27 Kip1 cell cycle regulator ( 23 ). |