| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-go:0005125::positive |
| Nodes | AKT1 --+> cytokine activity |
| References | 5 |
| Connectivity | 2 |
| MedLine Reference | 10446202:1022 |
|---|---|
| Sentence | Cytokines, growth factors, and certain oncogenes have been shown to be effective inhibitors of apoptosis, and in many situations, this anti-apoptotic effect is mediated by the PI3K-induced activation of PKB/Akt ( 18-23 ). |
| MedLine Reference | 11350959:1033 |
|---|---|
| Sentence | Following stimulation of cells extracellularly with ( e.g. ) growth factors or cytokines, Akt is recruited to the plasma membrane and catalytically activated by phosphorylation at threonine 308 and serine 473 ( 19 , 33-35 ). |
| MedLine Reference | 12952968:1175 |
|---|
| MedLine Reference | 10974038:1213 |
|---|
| MedLine Reference | 12574380:1224 |
|---|