| Effect | positive |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:7157:out-urn:agi-go:0008083::positive |
| Nodes | TP53 --+> growth factor activity |
| References | 2 |
| Connectivity | 2 |
| MedLine Reference | 10783169:1167 |
|---|---|
| Sentence | Several growth factors and growth factor inhibitors, including IGFBP-3, TGF- alpha, and two TGF-eta family members, were also activated by p53, suggesting p53 might regulate the cells adjacent to a p53-activated cell in the body. |
| MedLine Reference | 10196169:1193 |
|---|---|
| Sentence | Possibly, the induction of Cox-2 by oncogenes ( 9 , 11 ), growth factors ( 42 ), and cytokines ( 6 ) may be enhanced in cells expressing mutant p53. |