| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:207:out-urn:agi-go:0003720::negative |
| Nodes | AKT1 ---| telomerase |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 12097303:1010 |
|---|---|
| Sentence | We also demonstrate that increased telomerase activity triggered by these cytokines is mediated by phosphatidylinositol 3'-kinase (PI3k)/Akt/ nuclear factor B (NF B) signaling. |
| MedLine Reference | 10224060:1140 |
|---|---|
| Sentence | Thus, these results, indicating that drugs affecting Akt kinase modulate both human telomerase activity and the phosphorylation of hTERT , suggest that human telomerase is activated by Akt kinase phosphorylation. |
| MedLine Reference | 11277998:4 |
|---|