| Effect | negative |
|---|---|
| URN | urn:agi-Regulation:inout-urn:agi-llid:5728:out-urn:agi-go:0004707::negative:phosphorylation |
| Mechanism | phosphorylation |
| Nodes | PTEN ---| map kinase |
| References | 3 |
| Connectivity | 2 |
| MedLine Reference | 10485474:1021 |
|---|---|
| Sentence | PTEN may also alter mitogen- activated protein kinase signaling (9) . |
| MedLine Reference | 9927060:1222 |
|---|---|
| Sentence | In addition, other pathways involving phosphatidylinositol 3,4,5-trisphosphate, Shc, and MAP kinase can also be modulated by PTEN in an increasingly complex network of signal transduction affecting cell growth and apoptosis (47 48 49) . |
| MedLine Reference | 10400703:1027 |
|---|