| Connectivity | 494 |
|---|---|
| Notes | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
| Hugo ID | 9588 |
| Name | PTEN |
| Description | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) |
| URN | urn:agi-llid:5728 |
| Cell Localization | Cytoplasm |
|---|
| GO Biological Process | cell migration |
|---|---|
| central nervous system development | |
| induction of apoptosis | |
| negative regulation of cell cycle | |
| protein amino acid dephosphorylation |
| EC Number | 3.1.3.67 |
|---|
| MGI ID | 109583 |
|---|
| Swiss-Prot Accession | O00633 |
|---|
| OMIM ID | OMIM:601728 |
|---|---|
| OMIM:153480 | |
| OMIM:158350 | |
| OMIM:156100 | |
| OMIM:137800 | |
| OMIM:176807 | |
| OMIM:176920 | |
| OMIM:188470 | |
| OMIM:276950 |
| Alias | Pten |
|---|---|
| Mmac | |
| TEP1 | |
| MMAC1 | |
| mutated in multiple advanced cancers 1 | |
| phosphatase and tensin homolog deleted on chromosome ten | |
| phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | |
| 2310035O07Rik | |
| A130070J02Rik | |
| phosphatase and tensin homolog | |
| RIKEN cDNA 2310035O07 gene | |
| BZS | |
| MHAM | |
| PTEN1 | |
| MMAC1 phosphatase and tension homolog deleted on chromosome 10 | |
| MGC11227 | |
| Bannayan-Zonana syndrome | |
| MMAC I | |
| Mutated in multiple advanced cancers 1 | |
| Mutated in multiple advanced cancers I | |
| Protein-tyrosine phosphatase PTEN | |
| PTEN I | |
| TEP I | |
| multiple hamartoma (Cowden syndrome) |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 29420 |
|---|---|
| 50557 | |
| 19211 | |
| 70161 | |
| 107201 | |
| 707 | |
| 4260 | |
| 5728 |
| RGD ID | 61995 |
|---|
| Pathway | Insulin Receptor Signaling |
|---|---|
| PTEN signaling | |
| moduleb_direct interactions | |
| moduleb_shortest paths | |
| moduleb_commontarget-complex | |
| moduleb_commontargets-functionalclass | |
| moduleb_commontarget_cell processes | |
| moduleb_proteins |
| Unigene ID | Rn.22158 |
|---|---|
| Mm.245395 | |
| Hs.253309 |
| Group | Phosphatases |
|---|---|
| moduleb |