Protein : AKT1


Connectivity	2977
Notes	The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Hugo ID	391
Name	AKT1
Description	thymoma viral proto-oncogene 1
URN	urn:agi-llid:207


Cell Localization	Cytoplasm
	Nucleus


GO Biological Process	anti-apoptosis
	positive regulation of cell growth
	protein amino acid phosphorylation
	signal transduction
	apoptosis
	apoptotic mitochondrial changes
	cell growth and/or maintenance
	germ cell development
	protein catabolism
	protein ubiquitination
	regulation of cell cycle
	G-protein coupled receptor protein signaling pathway
	nitric oxide biosynthesis
	response to heat


EC Number	2.7.1.-


MGI ID	87986


Swiss-Prot Accession	P31749


OMIM ID	OMIM:164730
	OMIM:181500


Alias	Akt1
	Akt
	v-akt murine thymoma viral oncogene homolog 1
	thymoma viral proto-oncogene
	RAC protein kinase alpha RAC-PK alpha
	murine thymoma viral (v-akt) oncogene homolog 1
	PKB
	PKB/Akt
	PKBalpha
	thymoma viral proto-oncogene 1
	RAC
	PRKBA
	KRAC
	Murine thymoma viral (v-akt) oncogene homolog-1
	serine/threonine protein kinase
	KRAC_HUMAN
	Akt1/PKB protein kinase
	RAC-ALPHA
	Akt I
	Akt/PKB
	AKTI
	C-AKT
	Murine thymoma viral (v-akt) oncogene homolog I
	PKB alpha
	Protein kinase B
	RAC-alpha serine/threonine kinase
	RAC-PK-alpha
	serine/threonine protein kinase B
	thymoma viral proto-oncogene I
	v-akt murine thymoma viral oncogene homolog I


RGD ID	2081


Pathway	ACH-R in apoptosis
	AKT signaling
	Inhibition of Apoptosis
	Insulin Receptor Signaling
	Jak-Stat Pathway from IL6 Receptor
	PTEN signaling
	CREB signaling
	Antiapoptotic Pathways From IGF-1R
	Mitochondrial control of Apoptosis
	Apoptosis
	moduleb_direct interactions
	moduleb_shortest paths
	moduleb_commontarget-complex
	moduleb_commontargets-functionalclass
	moduleb_commontarget_cell processes
	moduleb_proteins
	moduled_proteins